The Space Shuttle was a partially reusable low Earth orbital spacecraft system operated by the U.S. National Aeronautics and Space Administration (NASA), as part of the Space Shuttle program. Its official program name was Space Transportation System (STS), taken from a 1969 plan for a system of reusable spacecraft of which it was the only item funded for development. The first of four orbital test flights occurred in 1981, leading to operational flights beginning in 1982. They were used on a total of 135 missions from 1981 to 2011, launched from the Kennedy Space Center (KSC) in Florida. Operational missions launched numerous satellites, interplanetary probes, and the Hubble Space Telescope (HST); conducted science experiments in orbit; and participated in construction and servicing of the International Space Station. The Shuttle fleet's total mission time was 1322 days, 19 hours, 21 minutes and 23 seconds.

Shuttle components included the Orbiter Vehicle (OV), a pair of recoverable solid rocket boosters (SRBs), and the expendable external tank (ET) containing liquid hydrogen and liquid oxygen. The Shuttle was launched vertically, like a conventional rocket, with the two SRBs operating in parallel with the OV's three main engines, which were fueled from the ET. The SRBs were jettisoned before the vehicle reached orbit, and the ET was jettisoned just before orbit insertion, which used the orbiter's two Orbital Maneuvering System (OMS) engines. At the conclusion of the mission, the orbiter fired its OMS to de-orbit and re-enter the atmosphere. The orbiter then glided as a spaceplane to a runway landing, usually at the Shuttle Landing Facility of KSC or Rogers Dry Lake in Edwards Air Force Base, California. After landing at Edwards, the orbiter was flown back to the KSC on the Shuttle Carrier Aircraft, a specially modified Boeing 747.